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Weight Gain and Diabetes May be Linked to Bacteria in Your Gut

1/7/2015

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Humans have evolved a protection mechanism in regards to energy storage.  We do this through the accumulation of adipose (fat) tissue.  Over the past several decades developed nations have been more concerned with obesity over malnutrition.  The primary reason for this is our diets have also "evolved" by having foods high in calories, fat and sugars easily available to the consumer.  Other factors also play a role in our increasing rate of obesity.  Within the last few years evidence suggests that gut microbiota (population of  trillions of bacteria and other microbes living in intestines) provide an important role in energy harvest, storage and expenditure.  

A study from the American Journal of Gastroenterology from 2012 shows evidence that germ-free mice are protected against obesity.  It is only when gut microbes from conventionally raised animals are transferred to these mice that there are dramatic increases in body fat and insulin resistance.  

First, let me define conventionally raised animals.  Conventionally raised beef for example, will usually be given antibiotics during its life to keep it healthy. Frequently, it will also be given hormones to increase its size quickly. When it is time to finish the beef the cow will be transferred to a feedlot, a small, crowded area that doesn't allow the cow to move much. Here it will be fed a specially formulated feed until it is ready to be butchered. The feedlots are dirty, unsanitary, and unpleasant for both the animals and those that work with them.  This is in comparison to grass fed beef.  Grass fed beef, as defined by the AGA, (American Grass-fed Association) defines grass-fed animals as those that have eaten nothing but grass and forage from weaning to harvest, have not been raised in confinement, and have never been fed antibiotics or growth hormones. In addition, all AGA-Certified Producers are American family farms and their livestock is born and raised in the U.S.

The study mentioned above,  also showed that the composition of gut microbiota  differs in lean and obese humans and animals and can change rapidly in response to dietary factors. The gut microbiota may also influence the development of conditions causing low-level inflammation, such as obesity and type 2 diabetes, through systemic exposure to bacterial lipopolysaccharide derived from the intestinal microbes.  Lipopolysaccharides are  large molecules consisting of a lipid and a polysaccharide.  They are found in the outer membrane of gram negative bacteria and cause strong immune responses in animals.  Lipopolysaccharides send signals to certain cells that play a role in the immune system response.  This data suggests that modification of the gut microbiota may be a relevant therapeutic treatment for obesity and other metabolic disorders.

Although this study does prove that modification of the gut microbiome can help treat obesity and possibly diabetes type 2, there remains to be many unanswered questions requiring further research.  The most optimal composition of the gut microbiota is still poorly understood.  Attempting to modify the microbiome can be detrimental and should be pursued with caution. 

For more information on human microbiomes check out this link to Genome Magazine



For sources and other information click on links above
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    Author
    Dr. Suzanne Fuchs has a passion for nutrition, health and fitness.  She aims to connect the dots between our overall health and the substances that go into our bodies on a daily basis by using only evidence based medicine, science and expert advice.    
    Dr. Suzanne Fuchs currently practices concierge foot and ankle medicine and surgery in Palm Beach and Palm Beach Gardens, Florida at LuxePodiatry™ 
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    Dr. Suz Heals.com has provided sources for information that is not directly provided by our own sources.

    Dr. Suz Heals.com  is intended to be used for educational and information purposes only. Dr. Suz Heals.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Dr. Suz Heals .com.  If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Dr. Suz Heals.com.  Dr. Suz Heals.com does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. Dr. Suz Heals.com  and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Dr. Suz Heals.com.



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